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It suggests that an imbalance of calcium levels in cells precedes the signaling pathway malfunctions and neuronal deterioration observed in neurodegenerative diseases.

It has long been known that calcium ions (Camol; variation from the norm, even if slight, is detrimental when it persists [8].

These binding options affect the conformation of Ca M and its ability to bind to specific target Ca M-binding proteins.

Calcium ions perform their function primarily through binding to membrane or cytoplasmic proteins.